Prucalopride succinate

CAS No. 179474-85-2

Prucalopride succinate ( R-108512;R108512 )

Catalog No. M12709 CAS No. 179474-85-2

Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 36 Get Quote
25MG 45 Get Quote
50MG 61 Get Quote
100MG 104 Get Quote
200MG 163 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Prucalopride succinate
  • Note
    Research use only, not for human use.
  • Brief Description
    Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist.
  • Description
    Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors; targets the impaired motility associated with chronic constipation, thus normalizing bowel movements; induces contractions (pEC50=7.48) in the guinea-pig colon, demonstrates anti-cholinergic, anticholinesterase or nonspecific inhibitory activity and does not antagonise 5-HT2A, 5-HT2B and 5-HT3 receptors or motilin, CCK1 receptors.
  • Synonyms
    R-108512;R108512
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT4A ;5-HT4B
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    179474-85-2
  • Formula Weight
    485.96
  • Molecular Formula
    C22H32ClN3O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 36 mg/mL
  • SMILES
    COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
  • Chemical Name
    Butanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Prins NH, et al. Br J Pharmacol. 1999 Jul;127(6):1431-7.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov;13(11):1493-7.
3. Bouras EP, et al. Gut. 1999 May;44(5):682-6.
4. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
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