
Prucalopride succinate
CAS No. 179474-85-2
Prucalopride succinate( R-108512 | R108512 )
Catalog No. M12709 CAS No. 179474-85-2
Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
10MG | 36 | Get Quote |
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25MG | 45 | Get Quote |
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50MG | 61 | Get Quote |
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100MG | 104 | Get Quote |
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200MG | 163 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NamePrucalopride succinate
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NoteResearch use only, not for human use.
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Brief DescriptionPrucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist.
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DescriptionPrucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors; targets the impaired motility associated with chronic constipation, thus normalizing bowel movements; induces contractions (pEC50=7.48) in the guinea-pig colon, demonstrates anti-cholinergic, anticholinesterase or nonspecific inhibitory activity and does not antagonise 5-HT2A, 5-HT2B and 5-HT3 receptors or motilin, CCK1 receptors.
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In VitroCell Proliferation Assay Cell Line:A549 cells Concentration:10 μM Incubation Time:24, 48, 72 h Result:Repressed lung cancer cells proliferation.
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In VivoAnimal Model:Diabetes mellitus (DM) rat modelsDosage:5 μg/kg, 10 μg/kg Administration:Oral gavage, single daily for 2 weeks.Result:Accelerated colonic movement and shortened the colonic transit time, and markedly increased the expression levels of Ki67 .Increased expression of SOX10 in the columnar epithelial nuclei and enteraden (when at 5 μg/kg), and in the columnar epithelial cells, the nuclei of lamina propria cells and enteraden (when at 10 μg/kg). Significantly increased Nestin expression, which concentrated in columnar epithelial cells and the mesenchyme. (Nestin:a marker of enteric neural stem cells in the ENS).
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SynonymsR-108512 | R108512
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT4A |5-HT4B
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number179474-85-2
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Formula Weight485.9584
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Molecular FormulaC22H32ClN3O7
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 36 mg/mL
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SMILESCOCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
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Chemical NameButanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Prins NH, et al. Br J Pharmacol. 1999 Jul;127(6):1431-7.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov;13(11):1493-7.
3. Bouras EP, et al. Gut. 1999 May;44(5):682-6.
4. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
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