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Prucalopride succinate

CAS No. 179474-85-2

Prucalopride succinate ( R-108512;R108512 )

Catalog No. M12709 CAS No. 179474-85-2

Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Prucalopride succinate
  • Note
    Research use only, not for human use.
  • Brief Description
    Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist.
  • Description
    Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors; targets the impaired motility associated with chronic constipation, thus normalizing bowel movements; induces contractions (pEC50=7.48) in the guinea-pig colon, demonstrates anti-cholinergic, anticholinesterase or nonspecific inhibitory activity and does not antagonise 5-HT2A, 5-HT2B and 5-HT3 receptors or motilin, CCK1 receptors.
  • Synonyms
    R-108512;R108512
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT4A ;5-HT4B
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    179474-85-2
  • Formula Weight
    485.96
  • Molecular Formula
    C22H32ClN3O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 36 mg/mL
  • SMILES
    COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
  • Chemical Name
    Butanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Prins NH, et al. Br J Pharmacol. 1999 Jul;127(6):1431-7.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov;13(11):1493-7.
3. Bouras EP, et al. Gut. 1999 May;44(5):682-6.
4. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
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